Use the search bar to search by drug, manufacturer, or indication. You can also filter your search results by drug, manufacturer, or negotiation status.
To learn more about a specific file, click on a drug name. It will open its product card, which includes information about the manufacturer, indication (the approved use of a drug by Health Canada), and negotiation milestones.
There are 6 negotiation statuses, which reflect where the drug file is in the pCPA process:
Under consideration for negotiation
We’re considering the evidence and gathering other information to inform the negotiation approach, including eligibility for expedited negotiation pathways.
Active negotiation
Negotiation activities are underway for the drug, with our negotiation team and the manufacturer meeting regularly.
Concluded with an LOI
Negotiations ended successfully with mutually agreed-upon terms, and these terms are outlined in a letter of intent (LOI).
Concluded without agreement
Negotiating parties couldn’t agree on terms. Negotiations have ended without a pricing agreement for the drug.
Negotiation not pursued
It has been decided, in partnership with our member drug plans, not to engage in a negotiation. Typically, this is because the drug’s health technology (HTA) assessment reimbursement recommendations were negative, or “do not reimburse.” Other reasons, like the manufacturer declining to negotiate or a lack of supply of the drug in Canada, may be reflected in an accompanying status note.
Negotiation on hold
We began negotiation activities for the drug, but they’ve since been paused. An accompanying status note indicates whether the pause was requested by the manufacturer or the pCPA.
Learn more
To learn more about our negotiation processes, or where the pCPA fits into the Canadian drug reimbursement system, consult these pages:
Enhertu (trastuzumab deruxtecan)
Status:
Concluded with an LOI
Manufacturer:
AstraZeneca Canada Inc.
Indication:
Advanced or Metastatic Gastric Cancer or Gastro-esophageal Junction (GEJ) Adenocarcinoma
Last updated:
June 29, 2026
Enhertu (trastuzumab deruxtecan)
Status:
Concluded with an LOI
Manufacturer:
AstraZeneca Canada Inc.
Indication:
For the treatment of adult patients with unresectable or metastatic hormone receptor (HR)-positive, HER2-low (IHC 1+ or IHC 2+/ISH-) or HER2-ultralow (IHC 0 with membrane staining) breast cancer who have received at least one endocrine therapy in the metastatic setting and are not considered suitable for endocrine therapy as the next line of treatment.
Last updated:
June 29, 2026
Status:
Concluded with an LOI
Manufacturer:
Eli Lilly Canada Inc.
Indication:
Atopic dermatitis
Last updated:
June 26, 2026
Status:
Concluded with an LOI
Manufacturer:
Mirum Pharmaceuticals Inc.
Indication:
for the treatment of progressive familial intrahepatic cholestasis (PFIC) in patients 3 months and older.
Last updated:
June 26, 2026
Status:
Active negotiation
Manufacturer:
Eisai Limited
Indication:
Insomnia
Last updated:
June 26, 2026
Status:
Concluded with an LOI
Manufacturer:
Valorum Biologics LLC
Indication:
Multiple Indications
Last updated:
June 25, 2026
Status:
Concluded with an LOI
Manufacturer:
CSL Behring Canada Inc.
Indication:
Hereditary Angioedema
Last updated:
June 25, 2026
Symtuza (darunavir/cobicistat/emtricitabine/tenofovir alafenamide)
Status:
Concluded with an LOI
Manufacturer:
Janssen Inc.
Indication:
HIV-1 Infection
Last updated:
June 25, 2026
Status:
Concluded with an LOI
Manufacturer:
Cipher
Indication:
Acne Vulgaris
Last updated:
June 25, 2026
Keytruda (Active ENP) (pembrolizumab)
Status:
Active negotiation
Manufacturer:
Merck Canada Inc.
Indication:
Keytruda, for the treatment of adult patients with muscle-invasive bladder cancer (MIBC) who are ineligible for cisplatin containing chemotherapy, in combination with enfortumab vedotin, as neoadjuvant treatment and then continued after radical cystectomy as adjuvant treatment.
Last updated:
June 23, 2026