Use the search bar to search by drug, manufacturer, or indication. You can also filter your search results by drug, manufacturer, or negotiation status.
To learn more about a specific file, click on a drug name. It will open its product card, which includes information about the manufacturer, indication (the approved use of a drug by Health Canada), and negotiation milestones.
There are 6 negotiation statuses, which reflect where the drug file is in the pCPA process:
Under consideration for negotiation
We’re considering the evidence and gathering other information to inform the negotiation approach, including eligibility for expedited negotiation pathways.
Active negotiation
Negotiation activities are underway for the drug, with our negotiation team and the manufacturer meeting regularly.
Concluded with an LOI
Negotiations ended successfully with mutually agreed-upon terms, and these terms are outlined in a letter of intent (LOI).
Concluded without agreement
Negotiating parties couldn’t agree on terms. Negotiations have ended without a pricing agreement for the drug.
Negotiation not pursued
It has been decided, in partnership with our member drug plans, not to engage in a negotiation. Typically, this is because the drug’s health technology (HTA) assessment reimbursement recommendations were negative, or “do not reimburse.” Other reasons, like the manufacturer declining to negotiate or a lack of supply of the drug in Canada, may be reflected in an accompanying status note.
Negotiation on hold
We began negotiation activities for the drug, but they’ve since been paused. An accompanying status note indicates whether the pause was requested by the manufacturer or the pCPA.
Learn more
To learn more about our negotiation processes, or where the pCPA fits into the Canadian drug reimbursement system, consult these pages:
Status:
Concluded with an LOI
Manufacturer:
Knight Therapeutics Inc.
Indication:
Treatment of opioid-induced constipation (OIC) in adult patients with cancer and non-cancer pain who have had an inadequate response to laxative(s).
Last updated July 7, 2026
Status:
Concluded with an LOI
Manufacturer:
Theratechnologies Inc.
Indication:
As an adjunct to diet for the treatment of adults with familial chylomicronemia syndrome (FCS) to reduce triglyceride levels.
Last updated July 4, 2026
Alyftrek (vanzacaftor, tezacaftor, deutivacaftor)
Status:
Concluded with an LOI
Manufacturer:
Vertex Pharmaceuticals (Canada) Incorporated
Indication:
Cystic fibrosis, F508del or responsive CFTR mutation, 6 years and older
Last updated July 3, 2026
Status:
Under consideration for negotiation
Manufacturer:
Biogen Canada Inc.
Indication:
Friedreich's ataxia
Last updated June 30, 2026
Enhertu (trastuzumab deruxtecan)
Status:
Concluded with an LOI
Manufacturer:
AstraZeneca Canada Inc.
Indication:
Advanced or Metastatic Gastric Cancer or Gastro-esophageal Junction (GEJ) Adenocarcinoma
Last updated June 29, 2026
Enhertu (trastuzumab deruxtecan)
Status:
Concluded with an LOI
Manufacturer:
AstraZeneca Canada Inc.
Indication:
For the treatment of adult patients with unresectable or metastatic hormone receptor (HR)-positive, HER2-low (IHC 1+ or IHC 2+/ISH-) or HER2-ultralow (IHC 0 with membrane staining) breast cancer who have received at least one endocrine therapy in the metastatic setting and are not considered suitable for endocrine therapy as the next line of treatment.
Last updated June 29, 2026
Status:
Concluded with an LOI
Manufacturer:
Eli Lilly Canada Inc.
Indication:
Atopic dermatitis
Last updated June 26, 2026
Status:
Concluded with an LOI
Manufacturer:
Mirum Pharmaceuticals Inc.
Indication:
For the treatment of progressive familial intrahepatic cholestasis (PFIC) in patients 3 months and older.
Last updated June 26, 2026
Status:
Active negotiation
Manufacturer:
Eisai Limited
Indication:
Insomnia
Last updated June 26, 2026
Status:
Concluded with an LOI
Manufacturer:
Valorum Biologics LLC
Indication:
Multiple Indications
Last updated June 25, 2026